Glycation & Advanced Glycation End Products (AGEs)

Glycation occurs when sugars react nonenzymatically with proteins or other molecules. Some resulting advanced glycation end products can accumulate in long-lived tissues. In collagen, cross-linking can increase stiffness and alter elasticity; AGE-related signalling may also interact with oxidative and inflammatory pathways. Blood sugar patterns, age, and some cooking processes are relevant parts of this story.